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Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial

10.1016/j.hgmx.2016.06.011 5 ChowanadisaiW.BauerlyK

Endogenous GLP-1 acts in GLP-1Rs located in this region and reduces the intake of highly palatable foods by suppressing mesolimbic dopamine signaling, which controls the pleasure-directed acquisition of food [24]

PubMed Sebecic B, et al

The same paper also included a nested case-control component of 120,054 patients with T2DM followed for 7.4 years and observed a lower association between dementia and exposure to GLP-1RAs compared with other antidiabetics 39

Marys Hospital, The Catholic University of Korea) to evaluate the safety, tolerability, and pharmacokinetics of subcutaneous PG-102 in healthy individuals with overweight (body mass index 2530 kg/m), with exploratory pharmacodynamic and biomarker assessments