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J Clin Endocrinol Metab, 91(3):799-805

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This apparently minor structural modification profoundly alters receptor selectivity: PT-141 shows a MC4R and MC3R preference over MC1R , which dissociates pro-sexual and central anorexigenic effects from cutaneous pigmentary effects

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It was studied as a provocative diagnostic test of pituitary GH-secretory capacity and as a treatment for children with idiopathic growth-hormone deficiency, where daily bedtime injection increased height velocity in some patients

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