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This modification facilitates the interaction between Mecp2 and the histone modification histone H3 trimethylation at Lys36 (H3K36me3)

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Kapoor MP, et al

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An eGFR just below 60 typically indicates the presence of early-stage CKD and is also associated with a significantly increased risk of cardiovascular and any-cause mortality, kidney failure, acute kidney injury, or the progression of CKD