Neurogenesis is defective in the AD model, which is characterized by decreased proliferation and differentiation, diminished neuronal maturity, and reduced survival, before processes that may secondarily affect neurogenesis, such as neuronal loss, amyloid deposition, and inflammation
This low dose helps individuals acclimate to the medication, reducing the risk of side effects such as nausea and gastrointestinal discomfort
The titration schedule itself (0.25 0.5 1.0 1.7 2.4 mg at ~4-week steps) is not a research artifact
Carry a letter from your prescribing provider that includes the medication name, the reason for the prescription, and the expected duration of your trip
33 The clinical efficacy of SAM in the treatment of cholestasis associated with hepatic diseases has been reviewed
If patients do not tolerate the 2.4 mg dose, the dose can be decreased to 1.7 mg weekly