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doi: 10.1164/rccm.200612-1804OC 109 UsherLRLawsonRAGearyITaylorCJBingleCDTaylorGWet al

Common causes include: Pernicious anaemia Conditions affecting absorption in the stomach or intestines Certain medications Dietary insufficiency, particularly in strict vegan diets Increasing age Identifying the underlying cause is important because treatment recommendations may vary

The index of bioavailability (F) was calculated using the AUC data obtained in an intravenous pharmacokinetics study with the same test article (RBM Exp

Species differences in the distribution of drug-metabolizing enzymes in the pancreas