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The most useful nuance for readers comparing headlines: REDEFINE 1's 20.4% number is the treatment-policy estimand (closer to intention-to-treat what happens regardless of whether participants stayed on treatment)

Side effects can occur, however

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These include if you are pregnant or breastfeeding, have a disease that affects your intestines and how well you digest your foods, or if you have a strict diet that doesnt give you enough vitamins

it is continuously tuned by feedback from the small intestine (the ileal brake and duodenal nutrient sensing) so that the downstream gut is never overwhelmed

Medicine (Baltimore) 94:e643e647