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Conversely, higher body weight may require the full dose escalation to achieve meaningful results

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doi: 10.1542/peds.2005-1947

Indicators used to determine the signalling profile of peptides include cAMP and intracellular Ca 2+ mobilisation, which are involved in promotion of insulin release, and pERK1/2 that is part of the mitogenic signalling pathways activated via the GLP-1R 12