The role of dietary sugars in health: molecular composition or just calories
Off-target gene silencing remains a concern, since siRNAs with partial complementarity might inadvertently downregulate non-target mRNAs, while endogenous siRNAs processed by Dicer and RISC may exhibit less susceptibility to these inaccuracies
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Acknowledgements This work was supported by the Austrian Science Fund (10.55776/COE16, T.H.), the Swedish Research Council (2023-03058, T.H.), the Swedish Brain Foundation (FO2022-0300, T.H.), the Novo Nordisk Foundation (NNF23OC0084476, T.H.) and the European Research Council (ERC-2020-AdG-101021016
Carbohydrates Whole-grain carbohydrates should be present in the diet, as they have a lower glycemic index, as well as more dietary fiber, vitamins, and minerals, compared to their wheat counterparts
