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As adults are more susceptible to hyperammonemia, emergent hemodialysis is mandatory before referral to a reference center if ammonia levels are above 200 mol/l as the risk of cerebral edema is then above 55%
Additionally, NAC has been implicated in offering therapeutic benefits for psychiatric disorders, such as depression (Deepmala et al
It has been found that MELAS results from the A3243G mtDNA mutation which appears to be linked to autism [83]