Modulates Immune System: LDN helps regulate the immune system, which can be beneficial for autoimmune conditions like rheumatoid arthritis, multiple sclerosis, and Crohns disease
The JAK2 signaling pathway activates, leading to suppression of NF-B, one of the master switches controlling inflammation throughout the body
And for the production of neurotransmitters and neuromodulators, things like dopamine and serotonin
Complete Blood Count (CBC) : Can show anemia or large red blood cells (macrocytosis) characteristic of B12 deficiency [*]
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Timestamps: 0:00 Cold open the zero-studies finding 1:21 Why "overtrained" does four different jobs simultaneously 16:10 The FOR / NFOR / OTS taxonomy 19:43 The supercompensation model borrowed from endurance, never validated for resistance training 32:28 Austin's clinical differential for fatigue and declining performance 36:17 RT evidence what happens when researchers try to induce OTS through lifting 43:19 Austin what actually drives the complaints he sees in practice 47:30 Six theories for what causes overtraining syndrome 1:01:09 The biomarker problem why the T:C ratio and cortisol don't work 1:05:09 What your wearable is actually measuring (and what it isn't) 1:09:28 Austin testosterone levels in trained athletes and when to act 1:13:40 Heart rate variability limitations for strength training 1:15:36 Session RPE the monitoring tool that actually works 1:17:31 How common is overtraining syndrome, really
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