Email: [email protected] Received: 03 November 2024 / Revised: 04 December 2024 / Accepted: 05 December 2024 / Published: 28 December 2024 DOI: 10.31491/APT.2024.12.158 Abstract Fibrotic disorders, such as idiopathic pulmonary fibrosis, are characterized by the accumulation of myofibroblasts, cells responsible for excessive extracellular matrix deposition and tissue remodeling
Glutamine has been used topically, as an oral supplement, and intravenously to prevent and treat chemoradiotherapy-induced oral mucositis, with mixed results (Chaveli-Lopez 2016)
There are cumulating data on reduced GSH levels and the consequent increased susceptibility to oxidative stress in many human diseases, contributing to the onset and worsening of these conditions
In contrast to its inert effect on normal mammary epithelium cells, WA generated ROS and caused cell death in the MDA-MB-231 and MCF-7 breast cancer lines
That molecule, now known as GHK-Cu, has since been shown to influence the expression of more than 4,000 human genes, touching pathways involved in tissue repair, inflammation, antioxidant defense, nerve regeneration, and cancer suppression
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