retatrutide glucagon receptor the wonder drug: What's Established, What's Plausible, What's Still a Hypothesis — WellFounded - Founders Health & Concierge Performance Medicine ADA 2026: Retatrutide Revolution

In today's podcast, we're gonna talk about what's happening metabolically in perimenopause and menopause, and how changing hormones are influencing your metabolic health, and what is happening with visceral adiposity, so the fat that likes to pack around our organs

Now, researchers have uncovered another possible benefit

The findings were then combined, and meta-analyses were performed to examine and interpret the results

Likewise, GLP-1(9-36)amide could reverse AD-related alterations in hippocampal synaptic plasticity and memory deficits, but did not alter levels of APP and A in APP/PS1 mice (218)

Consistently with its low efficacy in beta-arrestin recruitment, which is involved in receptor endocytosis, the ability of tirzepatide to induce GLP-1R internalization is approximately 40% that of native GLP-1 while its effect on GIPR is similar to native GIP

doi: 10.1001/jamainternmed.2013.2720 221 KnapenLMvan DalemJKeulemansYCvan ErpNPBazelierMTDe BruinMLet al