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Our work establishes a new enzyme class for proximity labeling with promising properties and paves the way for future improvements

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The GHK Tripeptide and Its Copper Complex The GHK sequence glycine, histidine, lysine is small enough to qualify as a "signal peptide," meaning it interacts with cell-surface and intracellular targets to alter transcriptional programs rather than acting as a structural building block

In order to replenish the pool of ACh the acetate must be reactivated to acetyl-CoA so that it can participate in the choline acetyltransferase catalyzed reaction