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Politi, P., Cena, H., Comelli, M., Marrone, G., Allegri, C., Emanuele, E., & Di Nemi, U

Current clinical evidence from a meta-analysis of phase 2 and three studies of tirzepatide in participants with T2D indicates that tirzepatide treatment is not associated with an increased risk of MACE-4, a composite outcome comprising the four outcomes cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization due to unstable angina (HR = 0.80

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Intramuscular injection bypasses this variability entirely, delivering near-100% bioavailability directly into circulation

Intramuscular injections are generally preferred for lipotropic shots because they allow for faster absorption of the nutrients and may be more effective

However, evening injections work equally well if that fits your schedule betterthe pharmacokinetics remain identical