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The Venus Viva device used in this study is one commercial system for this approach

It states that branded tirzepatide, Mounjaro, is FDA-approved for type 2 diabetes, while compounded tirzepatide is prepared by licensed 503A pharmacies against individual prescriptions and is a distinct product category

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Standardized Acetylation Process : Each batch is carefully processed to ensure consistent acetyl group attachment, maximizing the protective effect that enhances cellular health delivery compared to non-acetylated forms

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Both formulations were mainly prescribed in patient at high (39.1% in oral and 31.6% in subcutaneous semaglutide group, respectively) or very high (45.2% in oral and 46.3% in subcutaneous semaglutide group, respectively) cardiovascular risk, without significant differences between the two groups (Supplementary Fig.S1v)