The vitamin D receptor (VDR)-PPAR crosstalk enhances adipocyte insulin responsiveness, while its suppression of the renin-angiotensin system lowers OS that interferes with insulin signaling (225)
When IGF-1 LR3 binds to the extracellular alpha subunits of IGF-1R, it triggers a conformational change that brings the intracellular beta subunits into close proximity, enabling trans-autophosphorylation of multiple tyrosine residues on the beta subunits' kinase domains
The curcumin analog EF24 is a novel senolytic agent
IV vitamins may not be suitable for you if you have kidney disease, heart disease, hypersensitivity or anaphylaxis, or if nutritional deficiencies are not the likely cause of your symptoms
Anti-oxidant and anti-aging benefits
Kanda E, Ai M, Yoshida M, Kuriyama R, Shiigai T