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Significant weight loss in patients with DM using GLP-1 agonist medications (GLP-1s) was observed

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Weight loss and lifestyle changes have proven to be effective in restoring menstrual regularity and reproductive function, improving hyperandrogenism, glucose and lipid metabolism, and insulin sensitivity, thus reducing cardiovascular risk in women with PCOS [18,19,20]

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VSMC phenotypic switching is characterized by transformation from a quiescent contractile to an activated synthetic phenotype, promoting proliferation and leading to the formation of the neointima, the pathological vascular compartment critical for the development of atherosclerosis

Clinical trials included participants up to age 75 with no significant safety concerns in older adults