A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+
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9% use it for 45+ days[] These safe therapeutic doses can significantly deplete glutathione in women who already have low baseline levels.[] Healthy individuals can tolerate up to 4g/day with only modest glutathione decrease, but individuals with compromised glutathione experience significant depletion even at therapeutic doses
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[DOI] [PMC free article] [PubMed] [Google Scholar] Schnekess B.O., Allard M.F., Lopaschuk G.D