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Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts

Other supportive evidence is the correlation of the rate of transport of a given substance with transcellular electrical resistance, in which lower transport rates of substances assumed to be transported paracellularly are observed in high-resistance, tight epithelia, although electrical resistance and the transport of marker molecules do not always coincide

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Overall, eight CSC DEGs were upregulated including epithelial cell-type associated ( Plau, Plaur, Aldh1a1, Bnip3, Mecom, Mgst1, Abcb1, Ndrg1 ), and 10 were downregulated, mostly genes related to embryonic, haematopoiesis, and immune cells ( Ly6a, Kitlg, Il2rg, Dll4, Mecom, C2 )