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13 These findings are consistent with results from the SURPASS-1 trial, in which tirzepatide at all studied doses significantly improved HbA1c over 40 weeks without increasing hypoglycemia risk

Beyond Weight Loss: Additional Benefits of GLP-1s These medications act on appetite-regulating pathways in the brain

Do I need to take these medications forever

Heart rate should be monitored, especially in patients with heart or blood vessel problems

Clinically, qualifying for GLP-1 therapy typically requires meeting one of two conditions: a BMI of 30 kg/m or greater, or a BMI of 27 kg/m or greater combined with an obesity-related comorbidity such as type 2 diabetes or cardiovascular risk factors

There are no clinical trials on this approach it's based on pharmacokinetic modelling and community experience