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Statements Author contributions AS: Conceptualization, Visualization, Resources, Validation, Formal Analysis, Project administration, Methodology, Data curation, Writing review & editing, Funding acquisition, Writing original draft, Investigation, Supervision, Software

Changes in the total glutathione pool size occur predominantly through oxidantinduced changes in the expression and post-translational activity of enzymes involved in both cysteine and glutathione synthesis ( Figure 8 )

More serious and rarer side effects include pancreatitis, bowel obstruction, and gallstone attacks

Glutathione holds Generally Recognized As Safe (GRAS) status for food products

As free CORT measurements were not feasible, levels of free plasma CORT were estimated based on plasma total cortisol, CBG and albumin concentrations with the following calculation [relative plasma total corticosterone0.85*relative plasma CBG*relative plasma total corticosterone)(0.10*relative plasma albumin*relative plasma total corticosterone)]

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