The diagnosis of PCOS will be established using the Rotterdam criteria, specifically phenotype A, characterized as concomitant presence of irregular menstrual cycles, hyperandrogenism, and polycystic ovarian morphology [21]
Washout periods between medications are generally not necessary
Mice with Y2R knockout in the hypothalamus have increased osteoblastic activity, mineralization rate, and bone mass, indicating that Y2R normally plays a catabolic role in stimulating cortical and cancellous bone formation [77]
IV administration optimises bioavailability, bypassing first-pass metabolism
L.2001Thionein/metallothionein- a metabolic link.14368369
FB1 often resulted in immune dysfunction, reduced intestinal barrier function, and increased intestinal cell death in the gut