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In contrast, a subsequent larger randomized controlled trial evaluating global non-motor outcomes including cognition, mood, and quality of life, did not find statistically significant overall improvements, suggesting that the benefits of GLP-1 agonists may be more domain-specific than generalizable across all non-motor symptoms [32]

Some patients with severe glutathione synthetase deficiency also develop recurrent bacterial infections, probably due to defective granulocyte function

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