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26 Side effects include hepatoxicity and neurotoxicity

These agents mitigate muscle atrophy by downregulating atrophy-related factors (myostatin, MuRF1, MAFbx) and upregulating myogenic transcription factors (MyoD, MyoG) via PKA/Akt/mTOR signaling

FIGURE 1 2.1.2 Non-cellular components in TME of HCC ECM containing extracellular substances, tumor vasculature system, exosomes, and cytokines are major non-cellular components in TME of HCC (Tahmasebi Birgani and Carloni, 2017)