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Now, nearly three decades later, peptides have gone from niche to nearly everywhere

Several mechanisms might explain possible benefits: Improved glycaemic control : Better blood glucose regulation may reduce endothelial dysfunction and microvascular damage, both implicated in ED pathophysiology Weight reduction : Significant weight loss can improve testosterone levels, reduce inflammation, and enhance vascular function Cardiovascular effects : GLP-1 agents may improve endothelial function and reduce cardiovascular risk factors that contribute to ED Reduced inflammation : These medications have been associated with anti-inflammatory effects that might benefit vascular health, though more research is needed Some observational studies have reported improvements in erectile function scores among men with diabetes treated with GLP-1 receptor agonists, though the evidence is limited and more robust research is needed

Mark Cuban (28:07): Well, it's called Cost Plus Wellness

The potential threat of this metabolic disease to the kidneys as well as the whole bodys bones and joints should not be underestimated

Then the larger TriNetX analysis presented at ACR 2025 more than 12,000 semaglutide users, propensity-matched showed lower risk of stiffness, swelling, pain, and synovitis at 30 days, 3 months, and a year

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