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The target is a total phenytoin level of 15-20 ug/mL, or an estimated free phenytoin level of 1.5-2 ug/mL after albumin correction (more on this below)

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Nox2 knockout mice show attenuated cardiac dysfunction, reduced oxidative stress, and preserved sympathetic innervation compared to wild-type mice after doxorubicin treatment [77]

Not only the environmental factors, but the biochemistry also supports their combination