/ Take the following dose on Tuesday, and then finally reach Wednesday the week after
By activating both GIP and GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, and slows gastric emptying
If no progress emerges after 8 weeks despite optimization, dose escalation or alternative medications (like tirzepatide or dual-compound protocols) become appropriate next steps
[91] observe that brain KBs and blood glucose are inversely correlated such that a systemic drop in blood sugar (in part due to increased uptake into the brain), is associated with increased systemic production and cerebral uptake of KBs
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