It set out to compare current oral semaglutide products against orforglipron, which is also taken as a daily tablet
It is not yet approved for routine prescribing, and the final licensed dose, availability, long-term safety profile and prescribing guidance are not yet confirmed
In contrast, GLP-1 injections typically produce 15-25% weight loss in clinical trials
But the higher doses required for weight loss (absent a diabetes diagnosis) create more side effects, and at the end of the day, they arent cost-effective
They are also used for people living with obesity (defined as a body mass index, or BMI, of 30 or more) or overweight individuals (BMI of 27 or more) who have related health issues like high blood pressure or cholesterol
For semaglutide users, specific strains within these families stand out: Lactobacillus rhamnosus GG has been extensively studied for its ability to prevent and treat diarrhea, which can be a side effect during the initial phases of semaglutide treatment
