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Continued treatment with the GIP/GLP-1 dual agonist tirzepatide is necessary to maintain weight loss for adults with obesity, according to findings from the SURMOUNT-4 trial published in JAMA
"Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis"
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These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]
Creating these foundational lifestyle changes ensures long-term success and prevents weight regain
7 Center of General Education, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan
