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Y., et al
NICE recommends GLP-1 receptor agonists for type 2 diabetes when metformin and other oral medications fail to achieve adequate glycaemic control, particularly with BMI 35 kg/m or weight-related comorbidities
Some protein-rich foods help to prevent the de-activation of GLP-1 (Miguens-Gomez 2021)
Upon its secretion from the gut, GLP-1 activates GLP-1Rs located on the vagus nerve afferents, which leads to vagal glutamatergic excitation of PPG expressing neurons in the NTS [30]
However, a lower rate of cardiovascular death and heart failure hospitalizations was seen [24]
labeling for exenatide in 2007
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