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It is reported that stimulation of human adherent PBMCs with Plasmodium falciparum -infected red blood cells or the malaria crystal hemozoin followed by stimulation with TLR2 ligands can induce increased production of pro-inflammatory cytokines (163)

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Chemically, ALA contains a dithiolane ring that can undergo reduction to dihydrolipoic acid (DHLA) in the body

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