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Liraglutide (Saxenda), tirzepatide (Zepbound), and semaglutide (Wegovy) are FDA-approved for long-term use

Phase 2 trials test a drug on a few hundred participants over a year or so to establish efficacy and identify side effects

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doi: 10.6065/apem.2017.22.3.145 46 KopchickJJBerrymanDEPuriVLeeKYJorgensenJOL

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