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Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

This choice affects cost, safety, convenience, and long-term access

Life changes: Life changes can impact whether its safe or appropriate to continue semaglutide

Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma