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The first case is believed to have been detected in Ohio in the late 1960s but the illness was not widely diagnosable until the 90s

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Potential Side Effects of Fat Burners Moskovitz explained, Supplements marketed as fat burners generally contain caffeine and other stimulants which can be toxic with concerning side effects like anxiety, poor sleep, digestion issues and elevated heart rate

10.2217/14622416.8.6.567 Pharmacogenomics 67 LeeJ

Hocart SJ, Jain R, Murphy WA, Taylor JE, Coy DH (1999) Highly potent cyclic disulfide antagonists of somatostatin