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In DAPA-CKD, among 4,304 participants (67.5% with type 2 diabetes mellitus and 15.3% with prediabetes at baseline), the mean eGFR was 43.1 mL/min/1.73 m and the median UACR was 949 mg/g [47,52]

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After the esterification reaction, the reaction liquid was cooled to room temperature, and then the water collected in the water separator and a certain volume of water-carrying agent were added to the reaction liquid to fully adjust the specific gravity of the reaction liquid