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Longitudinal studies with multidimensional assessments and a wide range of outcome measures are also needed before a systematic application of ALC in clinical practice

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Skin-derived fibroblasts from individuals with the rare, monogenic variants of ASD fragile X (FXS) and tuberous sclerosis type 1 and type 2 were shown to have decreased IP3R-mediated calcium signaling (TSC) [151]

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Pearlman, D