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If the plateau persists despite these efforts, your provider might explore increasing your dose by 0.25 mg to 0.5 mg weekly, depending on how well youre tolerating the current dose

Risk of bias was assessed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool, and methodological quality was evaluated using the Newcastle-Ottawa Scale

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ORAI channels as potential therapeutic targets in pulmonary hypertension

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Some patients report minimal discomfort