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By six months, clinical studies such as the STEP 1 trial have shown average reductions of 7 to 12 percent of body weight, depending on lifestyle adherence and medical profile

When combined with semaglutide's gastrointestinal effects, patients face increased risk of electrolyte imbalance, dehydration, and worsened nausea

They found that participants lost an average of 15.1% of their total body weight over a 68-week period

White adipocyte dysfunction and obesity-associated pathologies in humans

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Gonciarz M, Mularczyk A, Szkudlapski D, Konturek SJ, Konturek PC