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Human trial data is limited to a handful of small pilot studies, and a 2025 University of Utah review concludes BPC-157 should be considered investigational

The Practical Maximum: ~53.8 mg/day Calculation: The average adult naturally consumes roughly 1.5 mg of copper daily through a standard diet

[1] [2] Tirzepatide is not recommended for patients with severe gastrointestinal disease, including severe gastroparesis

Those findings suggest an TGF--independent effect on renal fibrosis

doi: 10.1016/j.cell.2017.02.031