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( A recent meta-analysis reported comparing each strategy of combo therapy with the up-titration of basal insulin, showing no significant difference between the two approaches in HbA1c change, target HbA1c achievement rate, hypoglycemic risk, and body weight change ( Meanwhile, GLP-1RAs combined with each of the two FRC products show different temporal actions despite the same dosing frequency: lixisenatide of IGlarLixi is a short-acting agent, while liraglutide of IDegLira is a long-acting agent

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