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doi: 10.3389/fimmu.2022.997578 Received 19 July 2022 Accepted 24 November 2022 Published 08 December 2022 Volume 13 - 2022 Edited by Jorg Hermann Fritz, McGill University, Canada Reviewed by Cristian Loretelli, University of Milan, Italy

We investigated the incretin hormone system in monotremes because of their phylogenetic position as the most basal lineage amongst extant mammals

Significant improvements in waist circumference and multiple cardiometabolic risk factors

Weight loss results compared: the clinical trial data Numbers tell the story more clearly than any marketing language could

Adding the glucagon receptor, which is what retatrutide does, introduces an entirely new metabolic lever that the body has not adapted to

A critic to the use of a murine model deficient for intestinal GCG products, would be that other gut hormones might compensate for the lack of a functional GCG gene in that tissue, hence explaining the normalized incretin effect