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In addition to mechanistic data, several epidemiological studies have demonstrated that paternal diabetes is associated with increased risk of metabolic disorders in the next generation

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The investigators attributed the difference to the more rapid clearance of IGFBP-bound native IGF-1 versus the more sustained free-ligand exposure with the LR3 analog

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10.1038/sj.onc.1209168 127 MartnM.LoiblS.HyslopT.De la Haba-RodrguezJ.AktasB.CirrincioneC

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