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Karl Steinmetz and Tomas Lankenau for their English review of the manuscript and Jess Ortiz Urbina for his generous help

These compounds are not approved by the FDA for use in humans or animals

N Engl J Med (2017) 376(24):236775

Although these findings highlight integrin inhibitors as a viable class of ECM-targeted therapeutics, the majority of candidates remain at the preclinical or early clinical stage, and unresolved issues-including off-target toxicity, uncertainties in dose optimization, and limitations in delivery strategies pose substantial barriers to successful clinical translation (174)

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Skrzydlewska E, Kozuszko B, Sulkowska M, et al