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In the COR (Contrave Obesity Research) clinical trials, average weight loss was about 5-8% of body weight over 56 weeks

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In pancreatic cells, -arrestin-1 scaffolds ERK1/2, producing a delayed cytosolic phase with anti-apoptotic effects, while shaping GLP-1R trafficking (internalization and recycling) and the compartmentalization of cAMP, including sustained endosomal cAMP generation

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