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Given the substantial disease burden and adverse health outcomes associated with this comorbidity, interventions aimed at reducing this risk for depression in the Type 2 diabetes population are crucial, particularly among older adults who are disproportionately affected by both conditions. Guo noted that previous research suggested that GLP-1RAs a drug also used to treat obesity and kidney disease may alleviate depression symptoms due to its ability to cross the blood-brain barrier

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These reactions are actually quite slow unless catalyzed by an enzyme such as protein disulfide isomerase (PDI), an important enzyme that is particularly abundant in the endoplasm reticulum where protein folding occurs

Estimation of total phenolic content The total phenolic content was estimated using the method of Singleton et al