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The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]

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Eze et al., 2021

Indeed, Th1 cells specific for myelin antigens produce IFN- and lymphotoxin, which activate macrophages and microglia in lesions and directly cause demyelination

Szyposzynska A, Bielawska-Pohl A, Murawski M et al

(2) Modifying the expression of glycolytic and gluconeogenic enzymes