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"More limited amounts of healthier choices in the other food groups can improve health in addition to help manage weight. The diet has two main principles, according to the book: Follow an eating plan that's low in calories but includes foods that fill you up and that you enjoy eating Using physical activity to burn more calories The Mayo Clinic Diet eating plan is low in fat and calories and prioritizes whole grains, fruits and vegetables

Since GLP-1 and PYY are co-secreted from L-cells 24 , the failure of cinnamaldehyde and methyl syringate to raise circulating levels of GLP-1 seems paradoxical