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Cobalamin metabolism and its clinical aspects

There has been an increase recently in UK forum members reporting that their NHS B12 injections have been stopped or swapped for high dose oral B12

Intramuscular hydroxocobalamin injections are the UK first-line treatment for pernicious anaemia and neurological B12 deficiency

For your weekly dose, you need to turn the dose knob all the way until it stops AND the 1 icon is in the dose window

Testing revealed that the intra-assay coefficient of variation for the PAI-1 antigen ranged from 3.6-16.9% and the inter-assay coefficient of variation was 4.3-6.8%

As B12 is a water-soluble vitamin, it's generally considered safe (because any not used will be excreted via your urine), but even so you shouldn't take more than the recommended doses unless recommended to do so by your GP, as some studies have shown possible negative impacts of overdoing it