glutathione s-transferase Bacterial transferase General reaction catalyzed by glutathione

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Semaglutide and Tirzepatide are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

doi:10.1021/bi901180v

JD Hayes, JU Flanagan & IR Jowsey (2005) Glutathione transferases

Transient erythema, pruritus, or stinging may develop at the application site, typically resolving with continued use or brief treatment interruption

It also comprises key residues that facilitate the GSH-based nucleophilic attack on the electrophilic substrate, leading to the formation of a thioether bond and the subsequent detoxification of the substrate