In clinical trials of Wegovy, approximately 3% of participants reported experiencing this side effect
Clinical considerations : -Noncirrhotic MASH: There may be risks to the mother and fetus related to MASH with advanced liver fibrosis (e.g., increased risks of gestational diabetes, hypertensive complications, preterm birth, postpartum hemorrhage)
Energy restriction requires coordinated metabolic reorganization involving hepatic glucose output, adipose tissue lipolysis, skeletal muscle protein turnover, and mitochondrial fuel selection
5When Is Semaglutide Contraindicated
The dose should be individualized based on response, tolerability, safety, nutrition, body composition, and clinical goals
16 First, because of the peptide structure of semaglutide, the probability that it is degraded by pepsin in the stomach is significant